KMID : 0606920230310050544
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Biomolecules & Therapeutics 2023 Volume.31 No. 5 p.544 ~ p.549
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Regulation of the Gene Expression of Airway MUC5AC Mucin through NF-¥êB Signaling Pathway by Artesunate, an Antimalarial Agent
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Kim Kyung-il
Rajib Hossain Ryu Ji-ho Lee Hyun-Jae Lee Choong-Jae
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Abstract
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In this study, artesunate, an antimalarial agent, was investigated for its potential effect on the gene expression of airway MUC5AC mucin. The human pulmonary epithelial NCI-H292 cells were pretreated with artesunate for 30 min and then stimulated with phorbol 12-myristate 13-acetate (PMA), for the following 24 h. The effect of artesunate on PMA-induced nuclear factor kappa B (NF-kB) signaling pathway was also examined. Artesunate inhibited the glycoprotein production and mRNA expression of MUC5AC mucins, induced by PMA through the inhibition of degradation of inhibitory kappa B¥á (IkB¥á) and NF-kB p65 nuclear translocation. These results suggest artesunate suppresses the gene expression of mucin through regulation of NF-kB signaling pathway, in human pulmonary epithelial cells.
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KEYWORD
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MUC5AC, Pulmonary mucin, Artesunate
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